Nortriptyline

Hepatic N-demethylation of amitriptyline produces nortriptyline, the primary active metabolite requiring therapeutic drug monitoring to optimize dosing and minimize toxicity given the narrow therapeutic index of TCAs. Laboratory testing applications include clinical toxicology assessments in emergency departments evaluating suspected TCA overdose, forensic toxicology investigations, and drugs of abuse screening programs where TCA detection may indicate prescription compliance or polysubstance use. UTAK’s TCA Panel and DAU panels contain nortriptyline in lyophilized urine matrix at multiple concentration levels, supporting both immunoassay screening and confirmation methods used in clinical and forensic laboratories. Stock and custom QC solutions can incorporate related tricyclic antidepressants such as amitriptyline, imipramine, desipramine, doxepin, and other commonly monitored psychotropic medications to address your laboratory’s comprehensive antidepressant and therapeutic drug monitoring requirements.