Sirolimus

Sirolimus is a macrolide immunosuppressant that inhibits the mammalian target of rapamycin (mTOR) pathway, used in kidney transplant regimens for preventing organ rejection and in calcineurin inhibitor-sparing protocols to reduce nephrotoxicity. Laboratory testing applications include therapeutic drug monitoring in solid organ transplant programs where sirolimus trough concentrations guide dosing adjustments, monitoring combination immunosuppressive therapy with tacrolimus or cyclosporine, and clinical assessments in patients receiving sirolimus-eluting coronary stents or treatment for lymphangioleiomyomatosis. UTAK’s Immunosuppressants panels contain sirolimus in lyophilized whole blood matrix at multiple concentration levels, supporting immunoassay and mass spectrometry methods for assay performance monitoring. Stock and custom QC solutions can incorporate related immunosuppressants such as tacrolimus, cyclosporine, everolimus, and mycophenolic acid to address your laboratory’s comprehensive transplant therapeutic drug monitoring requirements.