Tacrolimus

Tacrolimus (FK506) is a calcineurin inhibitor macrolide immunosuppressant serving as the cornerstone of modern immunosuppressive regimens for preventing organ rejection following kidney, liver, heart, and lung transplantation. Laboratory testing applications include therapeutic drug monitoring in solid organ transplant programs where tacrolimus trough concentrations are routinely measured to guide dosing and minimize dose-dependent adverse effects, as well as monitoring in patients receiving tacrolimus for graft-versus-host disease prophylaxis following hematopoietic stem cell transplantation. UTAK’s Immunosuppressants panels contain tacrolimus in lyophilized whole blood matrix at multiple concentration levels, supporting immunoassay and mass spectrometry methods for assay performance monitoring. Stock and custom QC solutions can incorporate related immunosuppressants such as cyclosporine, sirolimus, everolimus, and mycophenolic acid to address your laboratory’s comprehensive transplant therapeutic drug monitoring requirements.